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Article

Evolution of prokaryotic DNA: intragenic and extragenic divergences observed with orthologs from three related species.

Molecular biology and evolution - 1 Jun 2004

Fuglsang Anders

Abstract excerpt

This study compared orthologous gene pairs from Escherichia coli K12, E. coli O157:H7 EDL933, Salmonella typhimurium LT2, and Yersinia pestis CO92 using only homologs of equal length, and differing nucleotides were counted and mapped. The data showed very clearly how the rates of divergence change with intragenic and extragenic position. The rate of synonymous mutation is lowest near start codons and near stop...

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PMID: 15044593
DOI: 10.1093/molbev/msh133

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