Association of SNPs linked to increased expression of SLC1A1 with schizophrenia.

doi:10.1002/ajmg.b.31249

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Article

Association of SNPs linked to increased expression of SLC1A1 with schizophrenia.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Jan 2012

Horiuchi Yasue, Iida Syuhei, Koga Minori, Ishiguro Hiroki, Iijima Yoshimi, Inada Toshiya, Watanabe Yuichiro, Someya Toshiyuki, Ujike Hiroshi, Iwata Nakao, Ozaki Norio, Kunugi Hiroshi, Tochigi Mamoru, Itokawa Masanari, Arai Makoto, Niizato Kazuhiro, Iritani Shuji, Kakita Akiyoshi, Takahashi Hitoshi, Nawa Hiroyuki, Arinami Tadao

Abstract excerpt

Glutamate is one of the key molecules involved in signal transduction in the brain, and dysfunction of glutamate signaling could be linked to schizophrenia. The SLC1A1 gene located at 9p24 encodes the glutamate transporter EAAT3/EAAC1. To investigate the association between the SLC1A1 gene and schizophrenia in the Japanese population, we genotyped 19 tagging single nucleotide polymorphisms (tagSNPs) in the SLC1A1...

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PMID: 22095641
DOI: 10.1002/ajmg.b.31249

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