Article
Parental origin of de novo constitutional deletions of chromosomal band 11p13.
American journal of human genetics - 1 Jul 1990
Huff V, Meadows A, Riccardi V M, Strong L C, Saunders G F
Abstract excerpt
One-half of all cases of Wilms tumor (WT), a childhood kidney tumor, show loss of heterozygosity at chromosomal band 11p13 loci, suggesting that mutation of one allele and subsequent mutation or loss of the homologous allele are important events in the development of these tumors. The previously...
Topics
- Alleles
- Child
- Chromosome Banding
- Chromosome Deletion
- Chromosomes, Human, Pair 11
- DNA
- Humans
- Infant
- Kidney Neoplasms
- Male
- Parents
- Polymorphism, Restriction Fragment Length
- Restriction Mapping
- Wilms Tumor