Parental origin of de novo constitutional deletions of chromosomal band 11p13.

Abstract excerpt

One-half of all cases of Wilms tumor (WT), a childhood kidney tumor, show loss of heterozygosity at chromosomal band 11p13 loci, suggesting that mutation of one allele and subsequent mutation or loss of the homologous allele are important events in the development of these tumors. The previously reported nonrandom loss of maternal alleles in these tumors implied that the primary mutation occurred on the...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Alleles
• Share to Child
• Share to Chromosome Deletion