Article
The transcription factor D-Pax2 regulates crystallin production during eye development in Drosophila melanogaster.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Oct 2009
Dziedzic Katharine, Heaphy Julie, Prescott Hallie, Kavaler Joshua
Abstract excerpt
The generation of a functioning Drosophila eye requires the coordinated differentiation of multiple cell types and the morphogenesis of eye-specific structures. Here we show that D-Pax2 plays a significant role in lens development through regulation of the Crystallin gene and because Crystallin is also expressed in D-Pax2(+) cells in the external sensory organs. Loss of D-Pax2 function leads to loss of Crystallin...
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