Article
Correlation between KIT expression and KIT mutation in melanoma: a study of 173 cases with emphasis on the acral-lentiginous/mucosal type.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Nov 2009
Torres-Cabala Carlos A, Wang Wei-Lien, Trent Jonathan, Yang Dan, Chen Su, Galbincea John, Kim Kevin B, Woodman Scott, Davies Michael, Plaza Jose A, Nash J W, Prieto Victor G, Lazar Alexander J, Ivan Doina
Abstract excerpt
The role of immunohistochemistry in the assessment of KIT status in melanomas, especially acral lentiginous/mucosal, is not well established. Although the reported prevalence of KIT mutations in acral lentiginous/mucosal melanomas is relatively low, detection of mutations in KIT can have profound therapeutic implications. We evaluated the efficacy of immunohistochemistry to predict mutations in KIT. One hundred...
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