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Distribution and clinical role of KIT gene mutations in melanoma according to subtype: a study of 492 Spanish patients.

European journal of dermatology : EJD - 1 Dec 2021

Millán-Esteban David, García-Casado Zaida, Manrique-Silva Esperanza, Virós Amaya, Kumar Rajiv, Furney Simon, López-Guerrero José Antonio, Requena Celia, Bañuls Jose, Traves Víctor, Nagore Eduardo

Abstract excerpt

BACKGROUND: KIT mutations are primarily associated with acral and mucosal melanoma, and have been reported to show higher prevalence in chronic sun-damaged (CSD) than non-CSD melanomas. OBJECTIVES: To investigate the prevalence of KIT mutations in melanoma according to subtype, and determine the clinical role of such mutations. MATERIALS & METHODS: We present results from a study of a Spanish population of 492...

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Cutaneous Melanoma Detection and Management
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Neoplasm Invasiveness

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Proto-Oncogene Proteins c-kit

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PMID: 33648909
DOI: 10.1684/ejd.2021.3971
PMCID: PMC7615026

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