Article
Involvement of NAD(P)H:quinone oxidoreductase 1 and superoxide dismutase polymorphisms in ulcerative colitis.
DNA and cell biology - 1 Dec 2009
Kosaka Toshihito, Yoshino Junji, Inui Kazuo, Wakabayashi Takao, Kobayashi Takashi, Watanabe Shinya, Hayashi Shigekazu, Hirokawa Yoshifumi, Shiraishi Taizo, Yamamoto Takayuki, Tsuji Mayumi, Katoh Takahiko, Watanabe Masatoshi
Abstract excerpt
Inflammatory bowel disease is a multifactorial disease. Oxidative stress has been thought to be one of etiologic factor for inflammatory bowel disease. The genes superoxide dismutase (SOD2) and NAD(P)H:quinone oxidoreductase 1 (NQO1) are involved in inflammation and oxidative stress. The purpose of the present case-control study with 134 patients with ulcerative colitis (UC) and 125 healthy controls was to...
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