Article
No association between a genetic variant of the p22PHOX component of NADPH oxidase C242T and ulcerative colitis.
Hepato-gastroenterology - 1 Jan 2000
Tahara Tomomitsu, Arisawa Tomiyasu, Fujita Hiroshi, Kamiya Yoshio, Nagasaka Mitsuo, Iwata Masami, Wang Fangyu, Shibata Tomoyuki, Nakamura Masakatsu, Yoshioka Daisuke, Okubo Masaaki, Takahama Kazuya, Watanabe Makoto, Nakano Hiroshi, Hirata Ichiro
Abstract excerpt
BACKGROUND/AIMS: Reactive oxygen species has been implicated in the development of ulcerative colitis (UC). NADPH oxidase, a major source of superoxide generation play a critical role in H. pylori related gastric inflammation. We aimed to clarify the effect of C242T polymorphism of p22PHOX, an essential component of NADPH oxidase on the risk of UC in a Japanese population. METHODOLOGY: 123 UC patients and 459...
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