Article
Glutathione S-transferase and P-glycoprotein in multidrug resistant Chinese hamster cells.
Biochemical pharmacology - 1 Jun 1990
Medh R D, Gupta V, Zhang Y, Awasthi Y C, Belli J A
Abstract excerpt
Glutathione S-transferases (GSTs) have been reported to be elevated in some forms of hepatic carcinogenesis, in multidrug resistant (MDR) cells exhibiting elevated P-glycoprotein, and in cells resistant to alkylating agents independent of the MDR phenotype. The reported elevation of GST in association with the MDR phenotype and the overexpression of P-glycoprotein along with induction of GST in hepatic...
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