Article
Polymorphism distribution and structural conservation in RNA-sensing Toll-like receptors 3, 7, and 8 in pigs.
Biochimica et biophysica acta - 1 Apr 2009
Morozumi Takeya, Uenishi Hirohide
Abstract excerpt
BACKGROUND: Viral genomic RNA-both single-stranded (ss) and double-stranded (ds)-is recognized by RNA-sensing Toll-like receptors (TLRs), notably TLR3 (dsRNA), TLR7 (ssRNA), and TLR8 (ssRNA). However, our knowledge of the roles of porcine TLR3, 7, and 8 in antiviral immunity is inadequate. METHODS: From information on exon-intron boundaries obtained through comparisons of the genomic and cDNA sequences,...
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