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Association of TNFd and IL-10 polymorphisms with mortality in unrelated hematopoietic stem cell transplantation.

Transplantation - 15 May 2006

Bettens Florence, Passweg Jakob, Gratwohl Alois, Chalandon Yves, Helg Claudine, Chapuis Bernard, Schanz Urs, Libura Jolanta, Roosnek Eddy, Tiercy Jean-Marie

Abstract excerpt

BACKGROUND: Non-HLA immunogenetic polymorphisms may influence outcome of hematopoietic stem cell transplantation (HSCT). In this study, we have determined the role of TNFa, TNFd, IL-10, IL-1, IL-1Ra, and IL-4R polymorphisms in patients transplanted with HSC of an unrelated donor. METHODS: The allelic variants of four SNPs (IL-10-1082, IL-1beta-511, IL-4R-3223, IL-4R-1902) and four microsatellites (TNFa, TNFd,...

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PMID: 16699452
DOI: 10.1097/01.tp.0000208591.70229.53

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