Article
Phenotype for activated tissue macrophages in histiocytic necrotizing lymphadenitis.
Pathology international - 1 Sept 2009
Nomura Yuko, Takeuchi Masanori, Yoshida Shiro, Sugita Yasuo, Niino Daisuke, Kimura Yoshizo, Shimizu Kei, Aoki Ryosuke, Suefuji Nobuko, Hirose Shinichi, Kikuchi Masahiro, Ohshima Koichi
Abstract excerpt
Macrophage polarization is divided into M1 and M2 type based on membrane receptors, cytokines, and chemokines. M1 expresses CD80, interleukin (IL)-6, IL-12, and chemokine receptor (CCR)7, while M2 expresses CD163, IL10, and chemokine ligand (CCL)22. The aim of the present study was to identify the properties of infiltrating tissue macrophages in histiocytic necrotizing lymphadenitis (HNL). Twenty patients with...
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