Article
Monitoring for multidrug-resistant Plasmodium falciparum isolates and analysis of pyrimethamine resistance evolution in Uige province, Angola.
Tropical medicine & international health : TM & IH - 1 Oct 2009
Menegon Michela, Pearce Richard J, Inojosa Walter O, Pisani Vincenzo, Abel Paulo M, Matondo Alexandre, Bisoffi Zeno, Majori Giancarlo, Ord Rosalynn, Warhurst David C, Roper Cally, Severini Carlo
Abstract excerpt
OBJECTIVES: To assess the extent of drug resistance in Uige through molecular genetic analysis and to test whether the dhfr triple mutant alleles present in Angola are of southeast Asian origin. METHODS: Seventy-one samples of blood from children admitted to the Pediatric Emergency Unit of Uige Provincial Hospital in 2004 were screened for resistance mutations at pfcrt, pfmdr1, pfdhfr, pfdhps and pfATPase6....
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