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Ultraefficient extracellular vesicle–guided direct reprogramming of fibroblasts into functional cardiomyocytes

25 Feb 2022

Abstract excerpt

Direct lineage conversion holds great promise in the regenerative medicine field for restoring damaged tissues using functionally engineered counterparts. However, current methods of direct lineage conversion, even those using virus-mediated transgenic expression of tumorigenic factors, are extremely inefficient (~25%). Thus, advanced methodologies capable of revolutionizing efficiency and addressing safety...

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PMID: 35213232
DOI: 10.1126/sciadv.abj6621

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