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Immortalization of Swine Umbilical Vein Endothelial Cells with Human Telomerase Reverse Transcriptase

1 Dec 2007

Abstract excerpt

Swine endothelial cells are commonly used as an in vitro model for studying features of the blood-brain barrier and some hemorrhagic diseases. However, primary cultures of swine cells have finite lifespans. To establish immortalized swine umbilical vein endothelial cells (SUVECs) using human telomerase reverse transcriptase (hTERT), the plasmid pCI-neo-hTERT was transfected into SUVECs by lipofection. Clones were...

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PMID: 18182851
DOI: 10.1016/s1016-8478(23)07351-x

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