Article
Modeling early retinal development with human embryonic and induced pluripotent stem cells.
Proceedings of the National Academy of Sciences of the United States of America - 29 Sept 2009
Meyer Jason S, Shearer Rebecca L, Capowski Elizabeth E, Wright Lynda S, Wallace Kyle A, McMillan Erin L, Zhang Su-Chun, Gamm David M
Abstract excerpt
Human pluripotent stem cells have the potential to provide comprehensive model systems for the earliest stages of human ontogenesis. To serve in this capacity, these cells must undergo a targeted, stepwise differentiation process that follows a normal developmental timeline. Here we demonstrate the ability of both human embryonic stem cells (hESCs) and induced pluripotent stem (iPS) cells to meet these...
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