Article
Molecular analysis of an ATP-dependent anion pump.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 30 Jan 1990
Rosen B P, Hsu C M, Karkaria C E, Owolabi J B, Tisa L S
Abstract excerpt
The plasmid-borne arsenical resistance operon encodes an ATP-driven oxyanion pump for the extrusion of the oxyanions arsenite, antimonite and arsenate from bacterial cells. The catalytic component of the pump, the 63 kDa ArsA protein, hydrolyses ATP in the presence of its anionic substrate antimonite (SbO2-). The ATP analogue 5'-p-fluorosulphonylbenzoyladenosine was used to modify the ATP binding site(s) of the...
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