Article
Novel deletion of HIV type 1 reverse transcriptase residue 69 conferring selective high-level resistance to nevirapine.
AIDS research and human retroviruses - 1 Sept 2001
Suzuki K, Kaufmann G R, Mukaide M, Cunningham P, Harris C, Leas L, Kondo M, Imai M, Pett S L, Finlayson R, Zaunders J, Kelleher A, Cooper D A
Abstract excerpt
A novel deletion of residue 69 of the HIV-1 reverse transcriptase (RT) gene was detected in combination with mutations V75I/V and F77L/F in a patient with partial virological response to several antiretroviral drug regimens, including stavudine (D4T), didanosine (DDI), lamivudine (3TC), saquinavir (SQV), and nevirapine (NVP). Longitudinal analysis of samples revealed that this deletion emerged upon reinitiation...
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