HIV Induces both a Down‐Regulation of IRAK‐4 that Impairs TLR Signalling and an Up‐regulation of the Antibiotic Peptide Dermcidin in Monocytic Cells

Abstract excerpt

HIV-infected individuals have an increased risk of invasive bacterial infections, even at early clinical stages with relatively normal CD4(+) T-cell counts. The pathogenic mechanisms behind this are not fully understood. However, an increasing number of studies indicate that HIV may impair the innate immunity to bacteria by infecting key cells of the monocyte/macrophage lineage. In this study, the effects of HIV...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Antimicrobial Peptides and Activities
• Share to Immune Response and Inflammation
• Share to Pneumocystis jirovecii pneumonia detection and treatment