Article

Cannabidiol prevents mucosal HIV-1 transmission by targeting Langerhans cells, dendritic cells, macrophages and T-cells

2026-01-07

Abstract excerpt

HIV-1 transmission depends on the structure and immune cell composition of mucosal epithelia. Transmission mechanisms involve direct infection of CD4 + T-cells or macrophages, and indirect viral transfer to CD4 + T-cells from Langerhans cells (LCs) or dendritic cells (DCs). LCs-mediated HIV-1 transfer is inhibited by the neuropeptide calcitonin gene-related peptide (CGRP), due to upstream activation in LCs of th...

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Literature Corpus work: f0b0a16e-6f57-5e59-831e-296d2818744c
DOI: 10.64898/2026.01.07.697949

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