Article
Some aspects of interindividual variations in the metabolism of xenobiotics.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] - 1 Aug 2003
Tamási V, Vereczkey L, Falus A, Monostory K
Abstract excerpt
Differences in drug metabolism among individuals are caused by numerous factors: differences in production and stability of mRNA of xenobiotic metabolizing enzymes, differences in the rate of enzyme synthesis and degradation, or enzyme inhibition. One of the most important reasons is genetic polymorphism of cytochrome P450 genes or cytochrome P450 regulatory factors. Nuclear receptors play great role in the...
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