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Article

DNA pol λ's extraordinary ability to stabilize misaligned DNA.

Journal of the American Chemical Society - 29 Sept 2010

Foley Meredith C, Padow Victoria A, Schlick Tamar

Abstract excerpt

DNA polymerases have the venerable task of maintaining genome stability during DNA replication and repair. Errors, nonetheless, occur with error propensities that are polymerase specific. For example, DNA polymerase λ (pol λ) generates single-base deletions through template-strand slippage within short repetitive DNA regions much more readily than does the closely related polymerase β (pol β). Here we present in...

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PMID: 20822183
DOI: 10.1021/ja1049687
PMCID: PMC3187873

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