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Analysis of Fecal DNA Methylation to Detect Gastrointestinal Neoplasia

22 Aug 2009

Abstract excerpt

BACKGROUND: The development of noninvasive screening tests is important to reduce mortality from gastrointestinal neoplasia. We sought to develop such a test by analysis of DNA methylation from exfoliated cancer cells in feces. METHODS: We first analyzed methylation of the RASSF2 and SFRP2 gene promoters from 788 primary gastric and colorectal tissue specimens to determine whether methylation patterns could act...

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PMID: 19700653
DOI: 10.1093/jnci/djp265

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