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Detection of aberrant methylation in fecal DNA as a molecular screening tool for colorectal cancer and precancerous lesions

1 Jan 2007

Abstract excerpt

AIM: To investigate the feasibility of detecting methylated fecal DNA as a screening tool for colorectal carcinoma (CRC) and precancerous lesions. METHODS: Methylated secreted frizzled-related protein gene 2 (SFRP2), hyperplastic polyposis protein gene (HPP1) and O6-methylguanine-DNA methyltransferase gene (MGMT) in stools from 52 patients with CRC, 35 patients with benign colorectal diseases and 24 normal...

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PMID: 17352030
DOI: 10.3748/wjg.v13.i6.950

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