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Article

Small molecule induced reactivation of mutant p53 in cancer cells.

Nucleic acids research - 1 Jul 2013

Liu Xiangrui, Wilcken Rainer, Joerger Andreas C, Chuckowree Irina S, Amin Jahangir, Spencer John, Fersht Alan R

Abstract excerpt

The p53 cancer mutant Y220C is an excellent paradigm for rescuing the function of conformationally unstable p53 mutants because it has a unique surface crevice that can be targeted by small-molecule stabilizers. Here, we have identified a compound, PK7088, which is active in vitro: PK7088 bound to the mutant with a dissociation constant of 140 μM and raised its melting temperature, and we have determined the...

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PMID: 23630318
DOI: 10.1093/nar/gkt305
PMCID: PMC3695503

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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