Article
The role of TGF-β in polycystic ovary syndrome.
Reproductive sciences (Thousand Oaks, Calif.) - 1 Jan 2014
Raja-Khan Nazia, Urbanek Margrit, Rodgers Raymond J, Legro Richard S
Abstract excerpt
Polycystic ovary syndrome (PCOS) is a common endocrine disorder characterized by chronic oligoanovulation and hyperandrogenism and associated with insulin resistance, type 2 diabetes, and cardiovascular risk. In recent years, genetic studies have linked PCOS to a dinucleotide marker D19S884 in the fibrillin 3 gene. Fibrillins make up the major component of microfibrils in the extracellular matrix (ECM) and...
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