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Article

Mutation of GGMP Repeat Segments of Plasmodium falciparum Hsp70-1 Compromises Chaperone Function and Hop Co-Chaperone Binding.

International journal of molecular sciences - 23 Feb 2021

Makumire Stanley, Dongola Tendamudzimu Harmfree, Chakafana Graham, Tshikonwane Lufuno, Chauke Cecilia Tshikani, Maharaj Tarushai, Zininga Tawanda, Shonhai Addmore

Abstract excerpt

Parasitic organisms especially those of the Apicomplexan phylum, harbour a cytosol localised canonical Hsp70 chaperone. One of the defining features of this protein is the presence of GGMP repeat residues sandwiched between α-helical lid and C-terminal EEVD motif. The role of the GGMP repeats of Hsp70s remains unknown. In the current study, we introduced GGMP mutations in the cytosol localised Hsp70-1 of...

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Identifiers

PMID: 33672387
DOI: 10.3390/ijms22042226
PMCID: PMC7926355

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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