Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

miRNA regulation through ligand occupancy of a nuclear hormone receptor.

Science signaling - 18 Aug 2009

Rougvie Ann E

Abstract excerpt

MicroRNAs (miRNAs) posttranscriptionally regulate gene expression, but the factors that direct transcription of miRNAs are not well characterized. Activation versus repression of key developmental miRNAs in Caenorhabditis elegans is directly mediated by ligand occupancy of a nuclear hormone receptor that acts to couple nutrient availability to developmental programs.

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3' Untranslated Regions
Share to Caenorhabditis elegans
Share to Caenorhabditis elegans Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochrome P-450 Enzyme System

Share to Green Fluorescent Proteins

Share to Ligands

Share to MicroRNAs

Share to Receptors, Cytoplasmic and Nuclear

Source

Identifiers

PMID: 19690329
DOI: 10.1126/scisignal.284pe52

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

miRNA regulation through ligand occupancy of a nuclear hormone receptor.PMID 19690329Read ↗

Nuclear hormone receptor regulation of microRNAs controls developmental progression.Semantic proximity Read ↗

Nuclear Hormone Receptors and Their Ligands: Metabolites in Control of TranscriptionSemantic proximity Read ↗

Nuclear hormone receptor NHR-49 is an essential regulator of stress resilience and healthy aging in Caenorhabditis elegansSemantic proximity Read ↗

Control of Caenorhabditis elegans life history by nuclear receptor signal transduction.Semantic proximity Read ↗

A feedback circuit involving let-7-family miRNAs and DAF-12 integrates environmental signals and developmental timing in Caenorhabditis elegans.Semantic proximity Read ↗

The nuclear receptor superfamily has undergone extensive proliferation and diversification in nematodes.Semantic proximity Read ↗

Nuclear receptors in nematodes: themes and variations.Semantic proximity Read ↗

The Nuclear Receptor HIZR-1 Uses Zinc as a Ligand to Mediate Homeostasis in Response to High Zinc.Semantic proximity Read ↗

A novel nuclear receptor/coregulator complex controls C. elegans lipid metabolism, larval development, and aging.Semantic proximity Read ↗

The divergent orphan nuclear receptor ODR-7 regulates olfactory neuron gene expression via multiple mechanisms in Caenorhabditis elegans.Semantic proximity Read ↗

Coordinate Regulation of Lipid Metabolism by Novel Nuclear Receptor PartnershipsSemantic proximity Read ↗

A developmental timer coordinates organism-wide microRNA transcriptionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.