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Article

Dissecting the effect of ALS mutation S375G on the conformational properties and aggregation dynamics of TDP-43370-375 fragment.

Biophysical chemistry - 1 Jul 2024

Xu Zhengdong, Zhang Jianxin, Tang Jiaxing, Gong Yehong, Zou Yu, Zhang Qingwen

Abstract excerpt

The aggregation of transactive response deoxyribonucleic acid (DNA) binding protein of 43 kDa (TDP-43) into ubiquitin-positive inclusions is closely associated with amyotrophic lateral sclerosis (ALS), frontotemporal lobar degeneration, and chronic traumatic encephalopathy. The 370-375 fragment of TDP-43 (370GNNSYS375, TDP-43370-375), the amyloidogenic hexapeptides, can be prone to forming pathogenic amyloid...

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Identifiers

PMID: 38615537
DOI: 10.1016/j.bpc.2024.107230

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