Article
Requirement for cotolerogenic gene products in the clonal deletion of I-E reactive T cells.
Science (New York, N.Y.) - 23 Feb 1990
Woodland D, Happ M P, Bill J, Palmer E
Abstract excerpt
T cells that express the T cell receptor V beta 5.2 domain react with the class II major histocompatibility complex (MHC) molecule I-E, and V beta 5.2+ T cells are deleted in mouse strains that express I-E glycoproteins. By examination of genetically defined recombinant inbred (RI) mouse strains, it was found that the deletion was dependent on the expression of I-E and one of a limited number of non-MHC gene...
Topics
- Animals
- CD4-Positive T-Lymphocytes
- Clone Cells
- Gene Expression
- Histocompatibility Antigens Class II
- Hybridomas
- Immune Tolerance
- Mice
- Mice, Inbred C3H
- Mice, Inbred DBA
- Mice, Transgenic