Article
V beta 17 T-cell deletion by endogenous mammary tumor virus in wild-type-derived mouse strain.
Proceedings of the National Academy of Sciences of the United States of America - 15 Apr 1992
Jouvin-Marche E, Cazenave P A, Voegtle D, Marche P N
Abstract excerpt
The wild-type-derived mouse strain PWK possesses a beta-chain variable region V beta 17a2 allele, which is expressed on mature T cells as part of the T-cell receptor of most mice expressing I-E, whereas V beta 17 T cells are deleted in all I-E+ laboratory mice bearing a V beta 17a1 allele. However, (PWK x CBA/J)F1 progeny and the wild-type-derived mouse strain MAI, which possesses the V beta 17a2 allele, display...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Base Sequence
- Cloning, Molecular
- Crosses, Genetic
- DNA
- Female
- Immunoglobulin Variable Region
- Lymphocyte Depletion
- Male