Article
Genetic variation in the human urea transporter-2 is associated with variation in blood pressure.
Human molecular genetics - 15 Sept 2001
Ranade K, Wu K D, Hwu C M, Ting C T, Pei D, Pesich R, Hebert J, Chen Y D, Pratt R, Olshen R, Masaki K, Risch N, Cox D R, Botstein D
Abstract excerpt
The kidney, by regulating the volume of fluid in the body, plays a key role in regulating blood pressure (BP). The kidney uses primarily sodium and, to a lesser extent, urea to maintain the appropriate volume of fluid. Genetic variation in proteins that determine sodium reabsorption and excretion is known to significantly influence BP. However, the influence of genetic variation in urea transporters on BP has not...
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