A novel mechanism of mycophenolic acid resistance in the protozoan parasite Tritrichomonas foetus.

doi:10.1016/0006-2952(90)90659-9

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Article

A novel mechanism of mycophenolic acid resistance in the protozoan parasite Tritrichomonas foetus.

Biochemical pharmacology - 1 Jan 1990

Hedstrom L, Cheung K S, Wang C C

Abstract excerpt

Tritrichomonas foetus relies primarily on the salvage of hypoxanthine to supply purine nucleotides. Mycophenolic acid disrupts T. foetus growth by specifically inhibiting inosine-5'-monophosphate (IMP) dehydrogenase, thereby blocking the biosynthesis of guanine nucleotides from hypoxanthine. We h...

Topics

Adenine
Animals
Cloning, Molecular
Drug Resistance
Guanine
Guanine Nucleotides
Hypoxanthine
Hypoxanthine Phosphoribosyltransferase
Hypoxanthines
IMP Dehydrogenase
Ketone Oxidoreductases
Mutation
Mycophenolic Acid
Tritrichomonas
Xanthine
Xanthines

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