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Article

Gene transfer in the evolution of parasite nucleotide biosynthesis

18 Feb 2004

Abstract excerpt

Nucleotide metabolic pathways provide numerous successful targets for antiparasitic chemotherapy, but the human pathogen Cryptosporidium parvum thus far has proved extraordinarily refractory to classical treatments. Given the importance of this protist as an opportunistic pathogen afflicting immunosuppressed individuals, effective treatments are urgently needed. The genome sequence of C. parvum is approaching...

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PMID: 14973196
DOI: 10.1073/pnas.0304686101

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