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Article

Steady-State Kinetics of the Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferase from <i>Tritrichomonas</i> <i>foetus</i>: The Role of Threonine-47

1 Mar 1998

Abstract excerpt

Tritrichomonas foetus, an anaerobic flagellated protozoan, causes urogenital trichomoniasis in cattle. Hypoxanthine-guanine-xanthine phosphoribosyl transferase (HGXPRTase), an essential enzyme in T. foetus required for salvaging exogenous purine bases, has been regarded as a promising target for anti-tritrichomonial chemotherapy. The steady-state kinetic analyses of synthesis and pyrophosphorolysis of IMP, GMP,...

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PMID: 9521725
DOI: 10.1021/bi972515h

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