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Article

Low density lipoprotein receptor-related protein 5 (LRP5) mutations and osteoporosis, impaired glucose metabolism and hypercholesterolaemia.

Clinical endocrinology - 1 Apr 2010

Saarinen Anne, Saukkonen Tero, Kivelä Tero, Lahtinen Ulla, Laine Christine, Somer Mirja, Toiviainen-Salo Sanna, Cole William G, Lehesjoki Anna-Elina, Mäkitie Outi

Abstract excerpt

OBJECTIVE: Mutations in the low-density lipoprotein receptor-related protein 5 gene (LRP5) underlie osteoporosis-pseudoglioma syndrome. Animal models implicate a role for LRP5 in lipid and glucose homeostasis. The objective was to evaluate metabolic consequences of LRP5 mutations in humans. DESIGN AND PATIENTS: Thirteen Finnish individuals with homozygous or heterozygous LRP5 mutations were assessed for bone...

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Source

Identifiers

PMID: 19673927
DOI: 10.1111/j.1365-2265.2009.03680.x

Genes

LRP5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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