Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Analysis of genetic variants of phosphodiesterase 11A in acromegalic patients.

European journal of endocrinology - 1 Nov 2009

Peverelli E, Ermetici F, Filopanti M, Elli F M, Ronchi C L, Mantovani G, Ferrero S, Bosari S, Beck-Peccoz P, Lania A, Spada A

Abstract excerpt

OBJECTIVES: Aberrant cAMP signaling is involved in the pathogenesis of somatotropinomas. The aim of the study was to screen acromegalic patients for the presence of variants of phosphodiesterase type 11A (PDE11A) gene, which have been recently identified in adrenocortical and testicular tumors. SUBJECTS AND METHODS: We sequenced the PDE11A gene-coding region in 78 acromegalic patients and 110 controls....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3',5'-Cyclic-GMP Phosphodiesterases
Share to Acromegaly

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Adenoma

Share to DNA, Neoplasm

Share to Immunohistochemistry

Share to Phosphoric Diester Hydrolases

Share to Pituitary Neoplasms

Share to Regression Analysis

Source

Identifiers

PMID: 19671705
DOI: 10.1530/EJE-09-0677

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Analysis of genetic variants of phosphodiesterase 11A in acromegalic patients.PMID 19671705Read ↗

Phosphodiesterases and cAMP Pathway in Pituitary DiseasesSemantic proximity Read ↗

Phosphodiesterase 11A (PDE11A) and genetic predisposition to adrenocortical tumors.Semantic proximity Read ↗

Genetics of familial acromegaly and pituitary gigantism.Semantic proximity Read ↗

Alterations of Phosphodiesterases in Adrenocortical TumorsSemantic proximity Read ↗

Adrenal hyperplasia and adenomas are associated with inhibition of phosphodiesterase 11A in carriers of PDE11A sequence variants that are frequent in the population.Semantic proximity Read ↗

The Pathogenic RET Val804Met Variant in Acromegaly: A New Clinical Phenotype?Semantic proximity Read ↗

A genome-wide scan identifies mutations in the gene encoding phosphodiesterase 11A4 (PDE11A) in individuals with adrenocortical hyperplasia.Semantic proximity Read ↗

Prevalence of AIP mutations in a large series of sporadic Italian acromegalic patients and evaluation of CDKN1B status in acromegalic patients with multiple endocrine neoplasiaSemantic proximity Read ↗

Phosphodiesterase 11A expression in the adrenal cortex, primary pigmented nodular adrenocortical disease, and other corticotropin-independent lesions.Semantic proximity Read ↗

Whole-Genome Sequencing of Growth Hormone (GH)-Secreting Pituitary Adenomas.Semantic proximity Read ↗

Polymorphisms in MEN1 and DRD2 genes are associated with the occurrence and characteristics of pituitary adenomas.Semantic proximity Read ↗

Pituitary acromegaly: not one diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.