Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetics of familial acromegaly and pituitary gigantism.

The Journal of clinical endocrinology and metabolism - 4 Jun 2026

De Sousa Sunita M C, Daly Adrian F

Abstract excerpt

The subset of pituitary adenomas with a heritable genetic basis is small but clinically striking. Somatotropinomas are amongst the most frequent pituitary adenoma subtypes encountered in this setting, with germline variants being enriched in familial acromegaly kindreds and people with a childhood or adolescent history of GH hypersecretion manifesting as pituitary gigantism. The genetic causes of familial...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acromegaly
Share to Adenoma
Share to MAX gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to NF1 gene

Share to Genetic Predisposition to Disease

Share to Genetic Testing

Share to Gigantism

Share to Pituitary Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 41965096
DOI: 10.1210/clinem/dgag151
PMCID: PMC13235292

Genes

AIP
CDKN1B
CHEK2
GNAS
MAX
MEN1
NF1
PAM
PRKACB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetics of familial acromegaly and pituitary gigantism.PMID 41965096Read ↗

Genetics of Acromegaly and GigantismSemantic proximity Read ↗

Clinical and Molecular Update on Genetic Causes of Pituitary Adenomas.Semantic proximity Read ↗

Acromegaly and genetics.Semantic proximity Read ↗

AIP mutations and gigantism.Semantic proximity Read ↗

Clinical and genetic characterization of pituitary gigantism: an international collaborative study in 208 patients.Semantic proximity Read ↗

Proteogenomic landscape and clinical characterization of GH-producing pituitary adenomas/somatotroph pituitary neuroendocrine tumorsSemantic proximity Read ↗

Pituitary gigantism: Causes and clinical characteristics.Semantic proximity Read ↗

Proteogenomic Landscape and Clinical Characterization of GH-Producing Pituitary AdenomaSemantic proximity Read ↗

The genetic background of acromegaly.Semantic proximity Read ↗

Phenotypic and genotypic features of a large kindred with a germline AIP variant.Semantic proximity Read ↗

The germline landscape of pituitary adenomas: established and emerging predisposition genes.Semantic proximity Read ↗

Genetics of Combined Pituitary Hormone Deficiency: Roadmap into the Genome EraSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.