Article
ALK gene copy number in lung cancer: Unspecific polyploidy versus specific amplification visible as double minutes.
Cancer biomarkers : section A of Disease markers - 1 Jan 2017
Caliò Anna, Bria Emilio, Pilotto Sara, Gilioli Eliana, Nottegar Alessia, Eccher Albino, Cima Luca, Santo Antonio, Pedron Serena, Turri Giona, Knuutila Sakari, Chilosi Marco, Vanzo Francesca, Bogina Giuseppe, Terzi Alberto, Tortora Giampaolo, Scarpa Aldo, Loda Massimo, Martignoni Guido, Brunelli Matteo
Abstract excerpt
BACKGROUND: Gains of a gene due to DNA polyploidy versus amplification of the specific locus are distinct molecular alterations in tumors. OBJECTIVE: We quantified copy number gains of ALK gene due to unspecific polyploidy versus amplifications of the specific locus in a series of non-small cell lung cancers. METHODS: The locus specific ALK copy (LSI) number status was evaluated in 205 cases by FISH. Ratio LSI...
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