Article
Oncogene mutations, copy number gains and mutant allele specific imbalance (MASI) frequently occur together in tumor cells.
PloS one - 14 Oct 2009
Soh Junichi, Okumura Naoki, Lockwood William W, Yamamoto Hiromasa, Shigematsu Hisayuki, Zhang Wei, Chari Raj, Shames David S, Tang Ximing, MacAulay Calum, Varella-Garcia Marileila, Vooder Tõnu, Wistuba Ignacio I, Lam Stephen, Brekken Rolf, Toyooka Shinichi, Minna John D, Lam Wan L, Gazdar Adi F
Abstract excerpt
BACKGROUND: Activating mutations in one allele of an oncogene (heterozygous mutations) are widely believed to be sufficient for tumorigenesis. However, mutant allele specific imbalance (MASI) has been observed in tumors and cell lines harboring mutations of oncogenes. METHODOLOGY/PRINCIPAL FINDINGS: We determined 1) mutational status, 2) copy number gains (CNGs) and 3) relative ratio between mutant and wild type...
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