Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hepatocellular carcinoma development induced by conditional beta-catenin activation in Lkb1+/- mice.

Cancer science - 1 Nov 2009

Miyoshi Hiroyuki, Deguchi Atsuko, Nakau Masayuki, Kojima Yasushi, Mori Akira, Oshima Masanobu, Aoki Masahiro, Taketo Makoto Mark

Abstract excerpt

The development of hepatocellular carcinomas (HCC) appears to be a multistep process that takes several decades in humans. However, the identities of specific gene alterations and their contribution to HCC pathogenesis remain poorly understood. We previously reported that Lkb1(+/-) mice spontaneously develop multiple hepatic nodular foci (NdFc) followed by HCC, and that the conditional activation of beta-catenin...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to AMP-Activated Protein Kinases
Share to beta Catenin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclin E

Share to Liver Neoplasms, Experimental

Share to Mice, Inbred BALB C

Share to Protein Serine-Threonine Kinases

Share to Signal Transduction

Share to Wnt Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 19671058
DOI: 10.1111/j.1349-7006.2009.01284.x
PMCID: PMC11159713

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hepatocellular carcinoma development induced by conditional beta-catenin activation in Lkb1+/- mice.PMID 19671058Read ↗

Overview of the molecular biology of hepatocellular neoplasms and hepatoblastomas of the mouse liver.Semantic proximity Read ↗

Deleting the β-catenin degradation domain in mouse hepatocytes drives hepatocellular carcinoma or hepatoblastoma-like tumor growth.Semantic proximity Read ↗

WNT/β-catenin signaling in the development of liver cancers.Semantic proximity Read ↗

Hepatomas with activating Ctnnb1 mutations in 'Ctnnb1-deficient' livers: a tricky aspect of a conditional knockout mouse model.Semantic proximity Read ↗

The tumor suppressor kinase LKB1: lessons from mouse modelsSemantic proximity Read ↗

Conditional deletion of beta-catenin reveals its role in liver growth and regeneration.Semantic proximity Read ↗

AXIN deficiency in human and mouse hepatocytes induces hepatocellular carcinoma in the absence of β-catenin activation.Semantic proximity Read ↗

Serine/threonine kinase TBK1 promotes cholangiocarcinoma progression via direct regulation of β-cateninSemantic proximity Read ↗

Lack of tumorigenesis in the mouse liver after adenovirus-mediated expression of a dominant stable mutant of beta-catenin.Semantic proximity Read ↗

Hepatomegaly in transgenic mice expressing an oncogenic form of beta-catenin.Semantic proximity Read ↗

Deleting <i>in vivo</i> β-catenin degradation domain in mouse hepatocytes drives hepatocellular carcinoma or hepatoblastoma-like tumorsSemantic proximity Read ↗

Unique phenotype of hepatocellular cancers with exon-3 mutations in beta-catenin gene.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.