Article
Mutations affecting thymus organogenesis in Medaka, Oryzias latipes.
Mechanisms of development - 1 Jul 2004
Iwanami Norimasa, Takahama Yousuke, Kunimatsu Sanae, Li Jie, Takei Rie, Ishikura Yuko, Suwa Hiroshi, Niwa Katsutoshi, Sasado Takao, Morinaga Chikako, Yasuoka Akihito, Deguchi Tomonori, Hirose Yukihiro, Yoda Hiroki, Henrich Thorsten, Ohara Osamu, Kondoh Hisato, Furutani-Seiki Makoto
Abstract excerpt
The thymus is an organ for T lymphocyte maturation and is indispensable for the establishment of a highly developed immune system in vertebrates. In order to genetically dissect thymus organogenesis, we carried out a large-scale mutagenesis screening for Medaka mutations affecting recombination activating gene 1 (rag1) expression in the developing thymus. We identified 24 mutations, defining at least 13 genes,...
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