Article
Thyroid hormone regulates hematopoiesis via the TR-KLF9 axis.
Blood - 16 Nov 2017
Zhang Ying, Xue Yuanyuan, Cao Chunwei, Huang Jiaojiao, Hong Qianlong, Hai Tang, Jia Qitao, Wang Xianlong, Qin Guosong, Yao Jing, Wang Xiao, Zheng Qiantao, Zhang Rui, Li Yongshun, Luo Ailing, Zhang Nan, Shi Guizhi, Wang Yanfang, Ying Hao, Liu Zhonghua, Wang Hongmei, Meng Anming, Zhou Qi, Wei Hong, Liu Feng, Zhao Jianguo
Abstract excerpt
Congenital hypothyroidism (CH) is one of the most prevalent endocrine diseases, for which the underlying mechanisms remain unknown; it is often accompanied by anemia and immunodeficiency in patients. Here, we created a severe CH model together with anemia and T lymphopenia to mimic the clinical features of hypothyroid patients by ethylnitrosourea (ENU) mutagenesis in Bama miniature pigs. A novel recessive...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.