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Article

The histone H4 basic patch regulates SAGA-mediated H2B deubiquitination and histone acetylation.

The Journal of biological chemistry - 8 May 2020

Meriesh Hashem A, Lerner Andrew M, Chandrasekharan Mahesh B, Strahl Brian D

Abstract excerpt

Histone H2B monoubiquitylation (H2Bub1) has central functions in multiple DNA-templated processes, including gene transcription, DNA repair, and replication. H2Bub1 also is required for the trans-histone regulation of H3K4 and H3K79 methylation. Although previous studies have elucidated the basic mechanisms that establish and remove H2Bub1, we have only an incomplete understanding of how H2Bub1 is regulated. We...

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Identifiers

PMID: 32245891
DOI: 10.1074/jbc.RA120.013196
PMCID: PMC7212633

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