Identification of genetic variants associated with response to statin therapy.

doi:10.1161/ATVBAHA.109.188474

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Article

Identification of genetic variants associated with response to statin therapy.

Arteriosclerosis, thrombosis, and vascular biology - 1 Sept 2009

Mega Jessica L, Morrow David A, Brown Alison, Cannon Christopher P, Sabatine Marc S

Abstract excerpt

OBJECTIVE: The purpose of this study was to test the association between polymorphisms in genes involved in either LDL cholesterol (LDL-C) metabolism or statin pharmacokinetics and LDL-C reduction with statins. METHODS AND RESULTS: 49 tagging and candidate polymorphisms in 9 genes were genotyped in 1507 post-ACS subjects randomized to atorvastatin or pravastatin. Two polymorphisms (rs7412, rs429358) that define...

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Identifiers

PMID: 19667110
DOI: 10.1161/ATVBAHA.109.188474

Genes

ABCB1
APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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