The Association Between Matrix Metalloproteinase-1, -2, -3, -9, and -12 Gene Polymorphisms and Atrial Fibrillation

Abstract excerpt

Atrial fibrillation (AF) is a prevalent cardiac arrhythmia associated with significant morbidity and mortality. Structural remodeling of the left atrium, particularly myocardial fibrosis, plays a key role in AF pathogenesis. Matrix metallo-proteinases (MMPs) are critical regulators of extracellular matrix remodeling and may contribute to atrial fibrosis through genetic variation. This case–control study included...

Topics

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• Atrial Fibrillation
• Epistasis, Genetic
• Genetic Association Studies
• Matrix Metalloproteinase 1
• Matrix Metalloproteinase 12
• Matrix Metalloproteinase 2
• Matrix Metalloproteinase 3
• Matrix Metalloproteinase 9

Identifiers and source

Literature Corpus work

e036d0f2-9a7b-5020-ae52-bfafe849b8bc

DOI

10.20944/preprints202605.1222.v1