Article
Enzymatic mechanisms of ethanol oxidation in the brain.
Alcoholism, clinical and experimental research - 1 Sept 2006
Zimatkin Sergey M, Pronko Sergey P, Vasiliou Vasilis, Gonzalez Frank J, Deitrich Richard A
Abstract excerpt
BACKGROUND: The exact enzymatic mechanisms of ethanol oxidation in the brain are still unclear. The catalase-mediated oxidation of ethanol was demonstrated in rat brain using incubation of brain homogenates with catalase inhibitors. The role of the alcohol dehydrogenase (ADH) or cytochrome P450-dependent system in this process is possible, but has not been confirmed. The objective of the study was to determine...
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