Article
FLG mutation p.Lys4021X in the C-terminal imperfect filaggrin repeat in Japanese patients with atopic eczema.
The British journal of dermatology - 1 Dec 2009
Nemoto-Hasebe I, Akiyama M, Nomura T, Sandilands A, McLean W H I, Shimizu H
Abstract excerpt
BACKGROUND: Mutations in the gene encoding filaggrin (FLG) have been shown to predispose to atopic eczema (AE). OBJECTIVES: Further to establish population genetics of FLG mutations in the Japanese population and to elucidate effects of FLG mutations to filaggrin biosynthesis in skin of patients with AE. METHODS: We searched for FLG mutations in 19 newly recruited Japanese patients with AE. We then screened 137...
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