Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic engineering of Candida utilis yeast for efficient production of L-lactic acid.

Bioscience, biotechnology, and biochemistry - 1 Aug 2009

Ikushima Shigehito, Fujii Toshio, Kobayashi Osamu, Yoshida Satoshi, Yoshida Aruto

Abstract excerpt

Polylactic acid is receiving increasing attention as a renewable alternative for conventional petroleum-based plastics. In the present study, we constructed a metabolically-engineered Candida utilis strain that produces L-lactic acid with the highest efficiency yet reported in yeasts. Initially, the gene encoding pyruvate decarboxylase (CuPDC1) was identified, followed by four CuPDC1 disruption events in order to...

Topics

Join the communities discussing this publication.

Candida
Cattle
Cloning, Molecular
Fermentation
Genetic Engineering

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Source

Identifiers

PMID: 19661682
DOI: 10.1271/bbb.90186

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic engineering of Candida utilis yeast for efficient production of L-lactic acid.PMID 19661682Read ↗

The effect of pyruvate decarboxylase gene knockout in Saccharomyces cerevisiae on L-lactic acid production.Semantic proximity Read ↗

Evolution of D-lactate dehydrogenase activity from glycerol dehydrogenase and its utility for D-lactate production from lignocellulose.Semantic proximity Read ↗

Experimental evolution reveals an effective avenue for d-lactic acid production from glucose-xylose mixtures via enhanced Glk activity and a cAMP-independent CRP mutation.Semantic proximity Read ↗

Lactic acid properties, applications and production: A reviewSemantic proximity Read ↗

Recent advancements in lactic acid production - a review.Semantic proximity Read ↗

Lactic acid production in Saccharomyces cerevisiae is modulated by expression of the monocarboxylate transporters Jen1 and Ady2.Semantic proximity Read ↗

Engineering of yeast pyruvate decarboxylase for enhanced selectivity towards carboligation.Semantic proximity Read ↗

High-level production of the low-calorie sugar sorbitol by Lactobacillus plantarum through metabolic engineering.Semantic proximity Read ↗

Efficient production of enantiomerically pure D-phenyllactate from phenylpyruvate by structure-guided design of an engineered D-lactate dehydrogenase.Semantic proximity Read ↗

Metabolic engineering of Escherichia coli for acetaldehyde overproduction using pyruvate decarboxylase from Zymomonas mobilis.Semantic proximity Read ↗

Molecular and functional characterization of two pyruvate decarboxylase genes, PDC1 and PDC5, in the thermotolerant yeast Kluyveromyces marxianus.Semantic proximity Read ↗

Metabolic engineering of the malonyl-CoA pathway to efficiently produce malonate in Saccharomyces cerevisiae.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.