Article
Protective role of genetic polymorphism of heat shock protein 70-2 for gastric cancer risk.
Digestive diseases and sciences - 1 Jan 2009
Shibata Tomoyuki, Arisawa Tomiyasu, Tahara Tomomitsu, Yoshioka Daisuke, Maruyama Naoko, Fujita Hiroshi, Kamiya Yoshio, Nakamura Masakatsu, Nagasaka Mitsuo, Iwata Masami, Takahama Kazuya, Watanabe Makoto, Hirata Ichiro, Nakano Hiroshi
Abstract excerpt
BACKGROUND: Heat shock protein 70-2 (HSP70-2) has a cytoprotective role in various conditions and also protects the gastric mucosa. Recently, polymorphism of HSP70-2 at position 1267 was suggested to be associated with carcinogenesis. We investigated the association of this polymorphism with the risk of gastric cancer in the present study. METHODS: We examined 223 patients (159 men and 64 women, mean age 64.8...
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